White pen

[ source ] Ancient Herbal no Acanthopanax records," the classics" only records of Acanthopanax bark. " Don't record" cloud: students of Hanzhoung and unjust sentence. " Shu" cloud: this place of Materia Medica of. " Materia Medica" cloud: this map of Jianghuai Lake South County all has. According to" China flora" records, acanthopanax senticosus distributed in Heilongjiang, Jilin, Liaoning and Hebei, Shanxi, and the" don't record"," Shu" and" Materia Medica Materia Medica through" the origin does not match. But according to the Chinese materia medica of Wujiapi original plant morphology description (see senticosus. ) analysis, used by the ancient Wujiapi should come from Acanthopanax Miq. ( Acanthopenax ) of various plants
[ ] B I Gu Pinyin name 's B
[ alias ] phalloidin, phalloidin fungus, bamboo, bamboo fungus, bacteria without dress him
[ source ]
Medicine source: as the PHALLACEAE fungal fruiting white pen.
Latin animal mineral name: Phallus impudicus L . Ex Pers.
Harvest and storage: summer, autumn collection, to soil impurities, clean, fresh or dried.
[ ] the original shape button spherical, size 4-6cm. White, mature surface cracks. The bell, brown, disc-shaped, central perforation, surrounded by a deep concave and convex ridge network. Surface sticky and smelly spore body. Cell surface quality, white, cylindrical, hollow. Length 8-12, diameter 1.5-2.5cm. Spore transparent, smooth, oval, ( 3.5-4.5 ) m x ( 1.5-2.5 ) ~ M.
[ ] habitat distribution
Ecological environment : in bamboo forest, forest edge, under the lawn, garden, with humus environment. Sometimes seen in the fire.
Resource distribution: distribution in the southwest and Jilin, Liaoning, Inner Mongolia, Hebei, Shaanxi, Xinjiang, Jiangsu, Zhejiang, Fujian, Taiwan, Guangdong, Tibet and other places.
[ character ]
The 1 trait identification of rhizome nodular irregular cylindrical, diameter 1.4-4.2cm, branched; surface gray-brown, with longitudinal bending wrinkled, often dense transverse wrinkles, lenticels horizontal length, micro projection and color is light. Cylindrical, more twisted, the diameter of 0.3-1.5cm; surface grayish brown or dark brown, wrinkled skin clear, thin, sallow peeling department. Hard, yellow-white section, fibrous. There are specific aroma, taste slightly hard, slightly bitter, astringent.
Character identification: features: white powder.
2.1. The bast fiber long, straight or slightly curved, some side end of wavy, slightly pointed or blunt circle, long 180-650 / m, 16-54 / m diameter, wall thickness of 4-18 m, the apertures thick and dense, visible surface inclined to make germanium texture, some cell with thick diaphragm.
2 calcium oxalate crystal diameter 11-64 m, edges and blunt; some crystal cell number of connected are arranged in rows, cluster crystal.
3 ray cell tangential longitudinal section view showed a round or oblong, tangential wall with diagonal interleaved or irregular mesh texture.
4 catheters for anilox and scalariform. In addition, a cork cells and fewer starch grains.
3: physical and chemical identification of thin layer chromatography: take this product 2G, plus the amount of methanol, made of 100% ( W / V ) solution, as for the sample solution. Another syringin, different kauri acid, beta sitosterol, 4 - methoxy salicylaldehyde as control products, respectively, on the same gel G-CMC thin-layer plate, using chloroform - methanol - water ( 7 : 3: 1, the clarified liquid ) launched 15cm, spray with 10% sulfuric acid solution, in a 105 DEG thermostat bake 4 minutes color. For the sample solution chromatography, only with the standard syringin, beta sitosterol chromatography on the corresponding position, show the same spots.
[ ] fruiting bodies containing the chemical composition of wheat sterols ( ergosterol ), uronic acid chitosan ( glycuronan ) ( ergosterol ), formaldehyde, acetaldehyde ( acetaldehyde ), phenyl acetaldehyde ( phenylacetadehyde ), crotonic aldehyde ( phenycroton-aldehyde ), oil, methyl mercaptan and hydrogen sulfide ( methylmercaptan ), ( hydrosul-furic acid ), two hydrogen chalcone ( dihydrochalcone ), acetic acid ( phenylacetie acid ) ( acetic acid ), acetic acid, propionic acid ( propionic acid ).
Pharmacological action [ ]
1 on the central nervous system of the effect of Acanthopanax Senticosus on rabbit EEG with mild activation, can weaken the chloral hydrate, sodium barbital and chlorpromazine inhibition. But another report, give the mice 1 intraperitoneal injection of five 40mg / kg thorn water extract, 80mg / kg, 160mg / kg, 320mg / kg, or daily intraperitoneal injection of 80mg / kg, 160mg / kg, 320mg / kg, 4-5 continuous day, all can appear sedative effect, reduce cyclobarbital sleep latency, prolong its sleep time; continuous administration sedation effect is stronger. Acanthopanax senticosus fruit volatile oil emulsion, alcohol extract and water extract 5ml / kg ( 1g crude drug / ml ) significantly prolonged in mice by intraperitoneal injection of sodium pentobarbital sleeping time. Intraperitoneal injection of Ciwujia extract, aqueous solutions of 10G / kg could obviously inhibit the caffeine and sodium benzoate in mice caused by increased locomotor activity. Intraperitoneal injection of 50% ethanol extract water soluble polysaccharide 0.5ml / only, can significantly extend the picrotoxin induced convulsion latency of mice. Acanthopanax senticosus on central nervous mechanism of action is unclear, but the inhibition was inhibited by some drug metabolizing enzymes, the excitatory effect differs from that of amphetamine compounds, does not affect normal sleep, but with neurological functional status and dose-related. Use of Acanthopanax senticosus feeding rats aged 2 months later, can make the striatum, midbrain and medullary MAO-B ( monoamine oxidase B ) activity decreased obviously, but the MAO-A activity increased 22% in hypothalamus. Tips of Acanthopanax senticosus may be mediated by changes in certain areas of the brain MAO activity and its isoenzymes, affect the monoamine levels and improve the functioning of the nervous system.
On 2 nonspecific stimulation: 2.1. The anti fatigue effect of acanthopanax root: the extract of Acanthopanax senticosus saponins on variety and fatigue animal model has the antifatigue effect of total glycosides, role than root extract is also relatively strong, extracts of ginseng and ginseng saponins strong. Mouse braking observed after collapse time results show, sting Five Bold glycosides have obvious anti-fatigue, Eleutheroside E effect is best. We filled the stomach of Ciwujia extract 20g / kg ( Medicine ), swimming time than the controls to extend 1 / 4, intraperitoneal injection also has the antifatigue effects. Rats were given intraperitoneal injections of Acanthopanax senticosus saponins 15mg / kg, swimming after a break of 1 hour can eliminate all the oxygen debt, while the control group rats oxygen consumption is still higher than the normal value of 62%. Acanthopanax senticosus saponins to rat swimming for 2 hours, can partially prevent muscle ATP, glycogen and lactate, pyruvate phosphate decrease and increase. Daily doses of acanthopanax bark extract 500mg / kg, a total of 21 hours, or in the water extract from clove resin phenol - two - O - beta - D - glucoside 50mg / kg, and continued for 18 days, can significantly extend the load swimming time of rats. From mouse rope-climbing test of Acanthopanax senticosus saponins have excitatory effects, anti fatigue effect. Forced vibrations of mice ( oscillation ) for 4 hours, to produce a state of fatigue, in swinging front gavage thorn five water extract 250mg / kg, 500mg / kg, 1000mg / kg, can significantly prevent the swing of mice induced by physical and grasping tone and rectal temperature drop. Swing after dosing, accelerated mice the changes of recovery, but on exploration, spontaneous motor movements and motor coordination in the reduction of no effect. Water extract on fatigue prevention effect than promoting recovery of function is stronger. We filled the stomach of syringin 100mg / kg can significantly prevent the mouse because of sway induced by grasping tense and probe motion reduction; 50mg / kg, 100mg / kg can accelerate the recovery; 100mg / kg can accelerate the recovery of autonomic activity. Syringin on fatigue prevention effect and promote recovery of basically the same. To mice syringaresinol - two - O - glucoside 25mg / kg, 50mg / kg, 100mg / kg, can prevent mice after swinging exploration activity and autonomic activity decreased, 25mg / kg, 100mg / kg dose can accelerate the recovery of the activity, promote recovery effect than the preventive effect of strong. The mouse forced the suspension of 30-60 minutes, suspension to mice immediately after intragastric administration of Acanthopanax senticosus extract 500mg / kg, 100mg / kg syringin, syringaresinol - two - O - glucoside 500mg / kg suspension, daily dosing 1 times, for 9 consecutive days or 10 days, caused by chronic stress in mice caused by fatigue, the results, the water extract and syringin on the stress sexual behavior in mice and reduce the rectal temperature decreased protective effect; syringaresinol - two - O - beta - D - glucoside on the sexual behavior in mice reduces, rectal temperature decreased and the recovery of memory disorders and adrenal enlargement has protective effect, but on the adrenal gland, hypothalamus tyrosine hydroxylase activity increase, adrenal gland and serum corticosterone content in no obvious change.
2.2. The anoxia tolerance to mice by intraperitoneal injection of Acanthopanax leaf total flavone 25mg / kg, significantly enhanced atmospheric, hypobaric hypoxia endurance, reducing overall oxygen consumption in mice. Hyperin has remarkable tolerance to hypoxia effect. Give mouse peritoneal injection of Ciwujia fruit volatile oil emulsion, alcohol extract, water extract ( 10g crude drug / kg ), alcohol extract, volatile oil significantly prolonged normobaric hypoxia mice survival time, but the effect of the aqueous extract is not obvious. We filled the stomach of Acanthopanax stem water extract 20g / kg, 40g / kg has remarkable tolerance to hypoxia effect.
2.3. The high and low temperature resistance, centrifugal resistance and anti radiation effect to mice with Ciwujia preparation, so that in the 16-17 C cold 2 minutes mouse rectal temperature decreased with decreasing, and can improve the resistance to high temperature endurance. To mice with Ciwujia extract 1 times a day, for 30 consecutive days, after Ray after acute radiation, and then by centrifugation, its survival as compared to a control group of 5 times; Acanthopanax Senticosus on acute, chronic radiation injury has a protective effect, such as prolonged exposure ( total dose 1620-7000r ), acanthopanax senticosus can prolong life 2 times in rats, and can improve the blood. Antibiotics may be used together with the extension is irradiated on day 60 ( total dose 3000r ) rat lives 3 times. Preventive effect of radioactive damage. Acanthopanax senticosus injection can improve by 1 for the total 4GY 60Co ray irradiation, resulting in the hematopoietic system radiation injury in mice and the cellular structure restoration, medication group of thymus cell ultrastructure recovery than the control group, the thymus tissue DNA content than the control group.
2.4. The anti stress effect of Acanthopanax senticosus 1mg / kg can significantly reduce the prehensile neck back suspension 24 h stress caused by method of rat tissue lipid peroxide content, and make almost depleted tocopherol recovery. Intraperitoneal injection of Eleutheroside 5mg / kg, due to its antioxidant and on the role of cholesterol metabolism, also make the stress effect weakened. Acanthopanax senticosus can change the stress response of the pathological process, make this process resulting in hypertrophy of the adrenal glands, adrenal cholesterol content was decreased, atrophy of the thymus and gastric bleeding reduction. When the rat to extract of Acanthopanax senticosus, in the water swimming for 5 hours, no hypertrophy adrenal gland, adrenal cholesterol content and not swimming in the normal control group rats had no significant difference, but not administration is swimming rat adrenal gland hypertrophy, cholesterol decreased significantly, there is obvious effect. This effect by Eleutheroside E is the strongest, Eleutheroside B is weaker, Eleutheroside C without action. Acanthopanax senticosus can prolong stress resistance period, rats during this period with the exception of adrenal fertilizer large, cholesterol content, spleen weight and animal appearance were normal weight, even better than no swimming rats increased high and fast. The stress response to failure period ( animal suspension 3 days) of Acanthopanax senticosus can prevent adrenal narrow, lower cholesterol, and thymus, spleen, liver, kidney and heart weight relative reduction. Acanthopanax senticosus extract gavage for 9 days, can antagonize the swimming stress induced mouse T, B lymphocyte cooperation function, NK cell activity and nonspecific suppressor cell function changes.




2.5: Antidotal Effect of Acanthopanax senticosus can enhance airframe to phosphoric acid trimethyl phenol ester and guitar forest detoxification capacity. Acanthopanax Senticosus Polysaccharide ( PES ) on carbon tetrachloride and thioacetamide induced rat liver poisoning are improved obviously.
3: anti-aging effects of Acanthopanax senticosus feeding 22 month-old rats after 2 months, erythrocyte lipid peroxide decreased by 17.75%, Na + - K + - ATP enzyme activity was elevated in 17.42%, prompting a delaying senility. Acanthopanax senticosus of hyperin and chlorogenic acid on rat hepatic microsomal lipid peroxidation inhibition.
4 Influence on immune function: 4.1. On monocyte macrophage phagocytic function of a system to mice or guinea pigs: effects of gavage daily alcohol water solution of Acanthopanax senticosus ( pharmacognosy ) 50g / kg, for 14 consecutive days, 15 days, significantly increased monocyte a phagocytic cells and peritoneal macrophage phagocytic capacity. Give mouse peritoneal injection of Ciwujia fruit volatile oil emulsion, alcohol extract, water extract 10ml / kg ( 1ml each contain a substantial quantity of 1g ), 1 times a day, for 5 consecutive days, alcohol extract significantly improves murine peritoneal macrophage phagocytosis of chicken erythrocyte phagocytic percentage and phagocytic index, water extract significantly increased the percentage of phagocytosis in contrast, volatile oil, reduces the phagocytic index. Mice were given daily intraperitoneal injection of Acanthopanax Senticosus Polysaccharide 0.67g / kg for 3 consecutive days, on the reticuloendothelial system phagocytic function had no significant effect, but the mice were given daily intraperitoneal injection of Acanthopanax Senticosus Polysaccharide ( PES-W ) and the separation of the monomer PES-A, PES-B 100mg / kg, for 5 consecutive days, can promote macrophage phagocytic function. 3 hours after infection of mice with Plasmodium chloroquine, first to mice 250mg / kg, give mice Acanthopanax tablets 12g / kg, the results of Acanthopanax senticosus can stop by chloroquine induced by mouse peritoneal macrophages and monocytes / macrophages phagocytosis drop system.
4.2. The effects on lymphocytes in mice: to gavage daily Acanthopanax senticosus extract 0.02ml / only, for 9 consecutive days, was prevented by swimming fatigue induced by T, B lymphocytes, killer cells, non-specific immune function decline. Mice were given daily intraperitoneal injection of Acanthopanax Senticosus Polysaccharide ( ASPS ) 12.5mg / kg, 25mg / kg, 50mg / kg and 100mg / kg for 4 consecutive days or 100mg / kg administered continuously for 9 days, were significantly enhanced in mice by bovine serum albumin ( BSA ) caused by delayed hypersensitivity. In vitro, can obviously promote the lipopolysaccharide ( LPS ) and concanavalin ( Con A ) on mouse spleen cell proliferation reaction. But another report to the guinea pig daily intraperitoneal injection of ASPS130mg / kg, for 4 consecutive days, on two dinitrochlorobenzene ( DNCB ) caused by delayed-type cutaneous hypersensitivity reaction without obvious effect. Acanthopanax senticosus polysaccharides can enhance the cytotoxic T lymphocyte ( CTL ) target cell killing activity of spleen cells in mice, and to all T cells after splenic cells have strong mitogenic effect, and can promote the Con A stimulation of murine spleen cells secrete interleukin 2. Mice were given intraperitoneal injection of Radix Acanthopanacis Senticosi ( Medicine ), 20g / kg of Acanthopanax Senticosus Polysaccharide 200mg / kg continuous 5-7 days, spleen weight increased significantly, the splenic macrophages increased significantly, increase the percentage rose combines 1.2-1.8 times. We filled the stomach of Acanthopanax leaf flavone 99mg / kg, 198mg / kg, administered continuously for 7 days, significantly increased in mice spleen weight. To young mice daily intraperitoneal injection of ASPS 340mg / kg, for 3 consecutive days, the spleen enlargement, thymus significantly reduced. Mice were given daily subcutaneous injection of cyclophosphamide in 30mg / kg, for 3 consecutive days, at the same time daily intraperitoneal injection of ASPS 340mg / kg, for 6 consecutive days, with cyclophosphamide group comparison, ASPS and cyclophosphamide and the spleen significantly larger, thymic narrowing is not obvious. Ethanol extract of Acanthopanax senticosus, possessing in vitro induction and activation of peripheral blood of patients with nasopharyngeal carcinoma T cell subsets ( T4 and T8 ) role, can make EB B cells infected with 3H-TdR infiltration, EB virus nuclear antigen ( EBNA ) positive cell percentage and 3 Ig secretion was significantly reduced, suggest that autologous T lymphocytes the acanthopanax senticosus injection induced with EB virus infection, inhibition of B cell activation, proliferation and differentiation.
4.3. Effect on antibody formation : LACA system and C57BL / 6 mouse inbred lines daily intraperitoneal injection of polysaccharide of Acanthopanax senticosus injection 12.5mg / kg, 25mg / kg, 50mg / kg, 100mg / kg 1, for medicine 9 days later, 25-100mg / kg polysaccharide of Acanthopanax senticosus significantly increased secretion of mouse IgG and IgM antibody secreting cells ( PFC ), suggesting enhanced specific humoral immune function. Mice were given daily intraperitoneal injection of the polysaccharide of Acanthopanax senticosus, on 4 consecutive days, was significantly increased in mice spleen PFC, 100mg / kg were increased in the mouse spleen PFC. Mice were given subcutaneous injection of Acanthopanax Senticosus Polysaccharide ( ASPS ) 0.67g / kg, for 3 consecutive days, the murine splenic antibody forming cells increased significantly. For rabbits and guinea pigs with daily intravenous injection of Streptococcus pneumoniae and Neisseria meningitidis 1 times, a total of 6 times, at the same time and intragastric administration of Radix Acanthopanacis Senticosi 10g ( drug ) / kg were administered for 23 days or 24 days, after stopping every 10 days to measure serum antibody concentrations in a total of 3 times, results show that promote antibody production of Acanthopanax senticosus.
4.4. The effects of interferon with 10 u g / ml Acanthopanax Senticosus Polysaccharide culture medium, the induced cells pretreated with 24-48 hours, using 150u / ml interferon promoter for 2 hours, proved of Acanthopanax Senticosus Polysaccharide significantly increases the ability of cells to produce interferon. Use of Acanthopanax Senticosus Polysaccharide ( PES ) and Eleutheroside B, D and E, S180 and S7811 leukemia cell lines were interferon inducing and promoting induced test, its drug promoting induced group potency of interferon inducible group was higher than conventional 10-20 times. The inducing ability to PES ( pure) the best, PES and B, D, E times. Kinetic experiments show that drug effects in 4-20 hour rises, 20-24 reached the peak after hours, gradually descending, the corresponding time of inducing interferon titers were significantly higher than that of conventional induced groups.
4.5. The antimutagenesis function of rabbits and mice by oral administration of Acanthopanax senticosus daily 24g / kg, 30g / kg, for 7 consecutive days, on benzene induced leucopenia in mice and rabbits have significant preventive effect. We filled the stomach of Ciwujia extract 50g ( drug ) / snake, on subcutaneous injection of cyclophosphamide induced neutropenia has a protective effect, and 50mg / kg vitamin B4, while 20g / kg small doses had no effect, but at this dose 3 days prior to delivery has significant effect in increasing leukocyte. Give mouse peritoneal injection of Ciwujia injection ( 100%) 0.2ml / only, for 7 consecutive days, can make white cells was significantly elevated, and inhibition of cyclophosphamide induced neutropenia, can also stimulate mouse bone marrow myeloid progenitor cell colony formation. Acanthopanax Senticosus Polysaccharide can reduce leukopenia induced by cyclophosphamide in mice. Mice were given daily subcutaneous injections of Acanthopanax stem extract 9g ( drug ) / kg for 4 consecutive days, on cyclophosphamide induced bone marrow nucleated cells reduce has obvious protective effect. Prior to the mouse daily intraperitoneal injection of Radix Acanthopanacis Senticosi 9g ( drug ) / kg for 6 consecutive days, the 60Co ray induced bone marrow nucleated cells reduce had significantly higher role. The subcutaneous injection of milk 1 hours before injection and at the same time, mice gavage of Acanthopanax senticosus injection of 50g / kg, the milk induced leukocytosis reaction inhibition.
5 antitumor effects of Acanthopanax senticosus extract on experimental tumor, drug induced tumors, cancer metastasis and spontaneous murine leukemia have certain effect, but also reduce the toxicity of anticancer drugs. Mice were given daily subcutaneous injections of Acanthopanax Senticosus Polysaccharide ( ASPS ) 0.34g / kg, for 10 consecutive days, significantly inhibited the mouse S37 and S180 growth, extended in ascitic hepatoma ( HEPA ) on L615 leukemia mice survival time, invalid. In vitro antitumor experiment shows, Acanthopanax Senticosus Polysaccharide on mouse hepatoma ascites cells had no direct role in killing. Prior to the mouse daily intraperitoneal injection of Acanthopanax Senticosus Polysaccharide 100mg / kg, 200mg / kg, for 3 consecutive days, after tumor inoculation was administered for 7 days, 12 days, 17 days, significantly inhibited the mouse thymoma ( EL-4 ) growth, prolong the survival time of mice with tumor. Acanthopanax Senticosus Polysaccharide on mice sarcoma S180 cells, human leukemia K562 cells in vitro have strong inhibition, its antitumor mechanism and biochemical characteristics related to changes in cell membrane, wherein the membrane phospholipid content, fatty acid composition and as a membrane phospholipid fractions of inositol phospholipid metabolism is important link. Acanthopanax senticosus extracts on some chemical substance induced animal tumors and spontaneous tumor also inhibit. As the mice given acanthopanax root extract at the same time or 1 week, 3 weeks, 6 weeks after the injection of urethane, can reduce the number of urethane induced lung adenoma. It also inhibits 6 - methyl thiouracil induced rat thyroid tumor. Against indole induced mouse bone marrow leukemia and reduce spontaneous murine leukemia. Acanthopanax root or rhizome extract added water can inhibit rat SSK sarcoma and Kirschner carcinoid tumor metastatic spread. Acanthopanax root aqueous extract and cytarabine combined with murine L1210 leukemia have additive effects on L1210 cells, the median effective dose of not more than 75 u g / ml.
6 anti-inflammatory effects in rats with gastric Acanthopanax alcohol soaking solution 25g ( drug ) / kg, on rat egg white foot swelling has obvious inhibiting effect. Mice were given intraperitoneal injection Acanthopanax stem extract 9g ( drug ) / kg or gavage 90g ( drug ) / kg, can inhibit the ear inflammation induced by xylene. Rats were given intraperitoneal injection of 9g ( drug ) / kg, inhibit the formaldehyde and carrageenin paw edema; administered continuously for 6 days, significantly inhibited granuloma. Daily to the rat gastric perfusion of Acanthopanax senticosus extract 10g / kg, for 21 consecutive days, on adjuvant induced rat foot early exudative inflammation and subsequent delayed allergic inflammation had significant inhibition effect. Rats by intraperitoneal injection of Acanthopanax senticosus extracts can inhibit capillary permeability increase induced by egg white. The removal of the adrenal gland of the rat, whether in winter and spring, acanthopanax senticosus extract can prevent formaldehyde of foot swelling development. Acanthopanax senticosus on the adrenal glands of mice, in summer, autumn and winter can reduce the scald edema, in the spring slightly anti-inflammatory effect.
7 the role of the cardiovascular system: the isolated rat heart after ligation of the left anterior descending coronary artery reperfusion ventricular fibrillation and ventricular tachycardia occurring rate decreased, so that the normal Dou Lv time is increased, so that the abnormal action potential decreased significantly. For intravenous injection of guinea pigs of Acanthopanax leaf total flavone 6mg / kg, the posterior pituitary hormone induced myocardial ischemia has a protective effect, jugular venous injection of hyperin could reduce or restoration of posterior pituitary hormone induced S-T segment shift, decrease in T wave amplitude increased, accelerated heart rate, against arrhythmia. Give mouse peritoneal injection of 35.6mg / kg acanthopanax root flavone, can very significantly increased 86Rb uptake of myocardium in mice. Acanthopanax senticosus saponin 25mg / kg, 50mg / kg, 100mg / kg intraperitoneal injection, can obviously increase the mouse cardiac 86Rb uptake rate. Acanthopanax senticosus saponins by intravenous injection of 25mg / kg, 50mg / kg, the ligation of the left anterior descending coronary artery ( LAD ) to produce acute myocardial infarction in 6 hours, can significantly reduce the myocardial infarction area, reduce the serum creatine kinase ( CK ) and lactate dehydrogenase ( LDH ) activity, significantly reduced LAD acute occlusion for 3 hours and 6 hours of serum free fatty acid ( FFA ) level. Acanthopanax senticosus saponin 25mg / kg, 50mg / kg intravenous injection on experimental myocardial infarction in dogs, can obviously increase of myocardial blood flow, reduced coronary resistance; can significantly slow down the heart rate, lower blood pressure, left ventricular pressure ( LVP ) and left ventricular pressure and maximum rate of rise ( DP / dtmax ); and reduced left ventricular pressure drop maximum rate ( DP / dtmax ) decreased and the left ventricular end diastolic pressure ( LVEDP ) increasing amplitude; while reducing myocardial oxygen consumption and myocardial oxygen consumption index, reducing myocardial oxygen utilization rate. Give in anesthetized cats by subcutaneous injection of Ciwujia extract 1-2ml / kg or intravenous injection of 0.05-0.5ml / kg, can dilate cerebral vessels, improve brain blood supply. To the anesthetized cat and rabbit vein injection of Ciwujia alcohol soaking solution of 2-4G / kg, can make blood pressure decreased 1.33-3.99kPa, 10-20 minutes, repeated dosing without rapid tolerance phenomenon. The isolated rabbit ear perfusion 30% root extract with vascular dilatation function. Acanthopanax senticosus can also make a cat hypotension returned to normal, the adrenaline caused by high blood pressure dropped to the normal range. Acanthopanax senticosus extracts can ease the ligation of the carotid artery and cerebral artery induced by acute cerebral ischemia of the pathological process, reduce ischemia compensatory response induced hypotension, low hemoglobin, low red blood cell count and ECG changes. Mice were given intraperitoneal injection of Acanthopanax leaf ethanol extract, can significantly prolong the mice after ligation of the bilateral common carotid artery of the survival time, also can prolong the sodium nitrite poisoning the organization survival time, on isoprenaline-induced myocardial oxygen consumption increased, the enhancement of anti hypoxia effect is obvious. Acanthopanax senticosus feed containing 24g / kg / day feeding rats aged 2 months, acanthopanax senticosus significantly increased Calmodulin Content and adrenergic activation of adenylate cyclase ( AC ) activity, suggestive of Acanthopanax senticosus through cyclic systems approaches to improve heart function.
8 on the role of platelet aggregation in vitro tests, acanthopanax senticosus extracts ( 0.275-2.2mg / ml ) on peanut four acid (AA ), two adenosine monophosphate ( ADP ) induced platelet aggregation was inhibited, and can inhibit AA induced platelet thromboxane B2 ( TXB2 ) generation; intravenous injection of 120mg / kg on rabbit AA, ADP induced aggregation inhibition. Acanthopanax senticosus leaf ethanol extract (equal quantity 25-70mg / ml ), in vitro experiments can inhibit ADP, collagen induced platelet aggregation in rabbits. To the rabbits following intravenous injection of 700mg / kg or rat intravenous injection of 1000mg / kg, can inhibit platelet aggregation induced by ADP. Mice were given intraperitoneal injection of Acanthopanax leaf ethanol extract 20g / kg, on collagen, epinephrine induced thrombosis of mice with reduced animal death and paralytic effect. Intravenous injection in rats of Acanthopanax leaf total flavone 60mg / kg, can very remarkably inhibited experimental thrombus formation. From Acanthopanax senticosus extract from the 3, 4 - two hydroxy benzoic acid and synthetic derivatives of 3, 4 - two ethyl four inhibition of peanut acid (AA), ADP and collagen induced platelet aggregation concentration were 0.5mg / ml, 1mg / ml, 0.25mg / ml and 0.1g / ml, 0.5mg / ml, 0.25mg / ml. Syringaresinol - two - glucoside 60 u g / ml inhibiting ADP induced platelet aggregation in 24% and collagen induced platelet aggregation in 75%.



9 the role of the endocrine system of acanthopanax root extract can reduce adrenaline rabbits induced by hyperglycemia and human nutrition hyperglycemia. Acanthopanax senticosus can regulate endocrine dysfunction. Not only can prevent the ACTH in rats induced by adrenaline hyperplasia, and can be reduced by hydrocortisone induced adrenal atrophy. Can prevent thyroid extract induced atrophy of thyroid gland, and can prevent the methylthiouracil caused by thyroid weight. Gavage of Acanthopanax senticosus extracts can be reduced by alloxan-induced diabetes in rat urine volume and increased glycogen content. The role of the cell membrane to lift diabetic beta lipoprotein ( diabetic p - lipoproteins ) on glucose uptake inhibition on. Acanthopanax root glycosides can also be activated by normal animal cells on glucose penetration ability. Acanthopanax senticosus saponins 100mg / kg, 200mg / kg mice or rats with repeated intraperitoneal injection, glucose, alloxan and adrenaline caused by high blood glucose has obvious inhibition. From Acanthopanax senticosus in the separation of the 7 polysaccharides have obvious hypoglycemic effect. To swim and swim for 15 minutes in the rat after subcutaneous injection of Ciwujia no obvious increase of adrenal and blood corticosteroid content, but in swimming for 5 hours, is significantly increased adrenal and blood corticosteroid content. There have been reports of long-term after administration of the rat adrenal medulla mast, on the adrenal glands of internal organization did not change significantly, while on the adrenal chromaffin tissue have the direct significant role. Male rats taking root and leaves were isolated from the total glycoside or Eleutheroside B, B1 and E, can increase the seminal and prostate weight and RNA content. Glycoside in castrated male animals prevention seminal and prostatic atrophy function. Taking containing acanthopanax senticosus extract feed hen produces egg quantity can be increased by 20.4%, egg weight increased by 24%, and increases the fallopian tubes in total nitrogen and protein, the hen's egg hatching rate is higher, hatched chicks raised its nitrogen and protein the new supersedes the old. Containing acanthopanax root dry weight of 0.3% feed can improve adult especially aging rat reproductive ability. Acanthopanax senticosus preparation can prevent the rabbit eating oxidized sunflower oil caused by sexual function is reduced, sperm concentration and activity is reduced and the reduction of spontaneous abortion and stillbirth in female rabbits. Prevent the oxidation induced hair loss and perioral necrosis and liver, myocardial pathological changes, and the effects of vitamin E is very poor.
10 on the metabolism and tissue regeneration effect: 10.1. On energy metabolism and carbohydrate metabolism in rats by subcutaneous injection of Acanthopanax senticosus extracts, resting state in rats of lactic acid and pyruvic acid in muscle and liver glycogen content in enhanced content reduced. The muscle load after 15 minutes, muscle lactate production is slower and energetic compounds using become more effective. In Acanthopanax role, to continue working, lactic acid, pyruvic acid, phosphoric acid, creatine and ATP concentrations returned to normal. At the same time anaerobic glycolysis and oxidative phosphorylation was strengthened, close to the initial level. Therefore, acanthopanax senticosus in muscle load can be more efficient use of energy reserves. The excitatory effect may be related to the enhancement of skeletal muscle anaerobic oxidation, increased oxidative substrate for. Rabbit oral Ciwujia 30 days, raise the blood sugar, hepatic glycogen and muscle glycogen and serum inorganic phosphorus, reduces hepatic and serum lactate and increased muscle lactate. Bullock intramuscular injections of Acanthopanax senticosus extracts can slightly improve hepatic gluconeogenesis and K, Ca the new supersedes the old. Rat swimming 2 hours can lead to glycogen and high-energy phosphate compounds more economical use of lactate, pyruvate metabolism, enhance, through aerobic oxidation for muscular activity to provide energy. Give Eleutheroside rat swimming for 2 hours, can partially prevent muscle ATP and glycogen or intramuscular lactate, pyruvate phosphate decrease and increase, it seems Acanthopanax in the new supersedes the old. Is to improve the nucleic acid and protein synthesis. Acanthopanax senticosus Decoction to mice after 9 weeks, the gastrocnemius muscle of succinate dehydrogenase ( SDH ) and malate dehydrogenase ( MDH ) activity were significantly improved, after short-term administration of fat, muscle and anterior tibial muscle in SDH activity has improved significantly, but the activity of MDH only increase trend. Stop after administration, the SDH and MDH activities declined, but the effect of Ciwujia Acanthopanax senticosus can still be maintained for 5 weeks, but also improve the mouse skeletal muscle enzyme activities, and increase their aerobic pathways of metabolic rate, in the mouse endurance training experiment, it can be seen the similar role of Acanthopanax senticosus.
10.2. On protein and nucleic acid of rat short-term muscle exercise ( swimming 15 minutes ), intramuscular total N amount is reduced, the residual N and N ( amino N ) increased amino, glutamine content decreased, protein hydrolysis activity increase; long muscle exercise ( swimming for 2 hours ), total N, NH3 and intramuscular blood urea levels were increased. Application of Acanthopanax senticosus extracts can make the muscle NH3, N and N reduce residual amino, tissue proteolytic activity was also reduced, intramuscular glutamine content increased, acanthopanax senticosus on N metabolism this beneficial effect is due to more efficient use of energy reserves. The swimming of rats after 15 minutes, the 32P incorporation into liver nuclear mRNA reduction, such as application of total glucosides of Acanthopanax senticosus in advance can restore speed. Acanthopanax senticosus saponins enhance human and animal movement resistance, which is the result of Acanthopanax senticosus can prevent the reduction of protein and nucleic acid synthesis. Mice were given intraperitoneal injection of ethanol extract of Acanthopanax senticosus ( pharmacognosy ) 1-3g / kg, for 3 consecutive days, can promote the brain DNA, RNA and protein biosynthesis. Acanthopanax Senticosus Polysaccharide and total glycosides can promote the nucleic acid and protein synthesis, increased mitotic cell number, enhanced DNA synthesis. Mouse liver after partial hepatectomy, intraperitoneal injection of Acanthopanax senticosus saponins 40mg / kg, can stimulate tissue regeneration, reduce liver diploid cell number. Another report of Acanthopanax senticosus can promote mRNA repair and glucose - 6 - phosphate synthesis.
10.3. The effects on lipid metabolism of Acanthopanax senticosus could improve the anaerobic oxidation of skeletal muscle, the oxidizable substrate increases, so that the body of earlier use of lipid oxidation as a source of energy. Rats were given subcutaneous injection of extracts in rats after swimming, 120 minutes after the blood of esterified fatty acid and phospholipid content and liver total fat content increased, also increased muscle lipid iodine value. To give female guinea pigs gavage daily Ciwujia extract 15mg / 0.4ml, successive 3 weeks, the guinea pig liver microsomes and intestinal mucosal homogenate of hydroxyl methyl amyl two acyl coenzyme A reductase ( HMGR ) activity were inhibited obviously. Acanthopanax senticosus on hepatic microsomal cholesterol 7 alpha hydroxylase has distinct activation effect. But on guinea pig serum total cholesterol and high density lipoprotein cholesterol concentrations were not significantly influence. With acanthopanax root extract and isotope labeling of cholesterol to male rabbit peritoneal injection, acanthopanax senticosus can reduce cholesterol induced hepatic cholesterol biosynthesis inhibition. Acanthopanax senticosus leaf total flavone 33mg / kg intraperitoneal injection, for 5 consecutive days, on Egg Yolk Emulsion rapid formation of hypercholesterolemia in mice have obvious improvement effects.
10.4. On inorganic salt metabolism: to experimental gastric dystonia leather by injection of atropine, the serum calcium, potassium, phosphorus, carotene content is lower than normal, and the extract of Acanthopanax senticosus injection can be normal. Bullock intramuscular injections of Acanthopanax senticosus can slightly improve calcium, potassium in the new supersedes the old.
11: in vitro antibacterial and antiviral effect of cup plate method experimental results show, alcohol extract of Acanthopanax senticosus ( 1: 1) or Decoction ( 1: 1) for Staphylococcus aureus has inhibitory action. The former to Neisseria, Escherichia coli has certain antibacterial effect. The division had to Lee bacteria infection of mice and rabbit subcutaneous injection of Acanthopanax senticosus extract, first hours is reduced in animal resistance to infection, reduction of serum complement levels in rabbits. Subsequently significantly improves the resistance to infection. Human type tubercle bacilli H37RV infection in guinea pigs can be observed in spleen, lung weight increase, lymph node swelling of liver, spleen, lung, caused by differences in the extent of lesions. On the infection of animals after intraperitoneal injection of polysaccharide of Acanthopanax senticosus, found in spleen, lung weight than that of the control group decreased, spleen, liver disease is reduced; the lumbar plexus and lymph node swelling rate decreased, OT reaction intensity significantly reduce, description of Acanthopanax Senticosus Polysaccharide on mycobacterial infections have certain resistance. On the guinea pig and mouse mite borne encephalitis, subcutaneous or oral administration of Acanthopanax senticosus extracts can be excited by its specific antiviral immunity.
12 the role of the respiratory system in mice with cough induced by measuring aerosol half away animals cough time (EDT50 ) shows, oral Acanthopanax senticosus root alcohol soaking solution of 10G / kg, 20g / kg and 40g / kg compared with the control group had significant effect on relieving cough. Phenol red method showed that the 10g / kg mice, 15g / kg and 20g / kg dose compared with the control group showed expectorant effect. L: 40 water solution on isolated guinea pig tracheal smooth muscle without relaxation.

The toxicity of [ ]
1: acute toxicity of mice with acanthopanax root alcohol water solution of 350g / kg gavage or Acanthopanax senticosus herb injection intraperitoneally, each rat 2g ( drug ) showed no abnormality. When the Acanthopanax senticosus root alcohol immersion solution intragastric doses increased to 500g / kg, mouse jumping disturbed, after 10 minutes to 1 hour quiet, return to normal, indicating its toxicity is very small. Acanthopanax root, stem, leaf water extracts on mice of each part of the median lethal dose for 14.5g. Eleutheroside E on mouse LD50 of 4.75g / kg. In mice after subcutaneous injection of Acanthopanax senticosus saponins LD50 of 4.75g / kg.
In 2 chronic toxicity: acanthopanax root alcohol soaking solution of 18.3g / kg mice gavage daily, for 15 consecutive days, or rabbit daily intramuscular injection of 6G / kg, for 15 consecutive days or daily to the rat gastric perfusion of Acanthopanax senticosus saponins 10mg / kg, a total of 60 days, blood, urinary organ weight check results there were not obvious toxic manifestations.
[ ] taste Gan; mild; warm
[ function ] Qufeng desiccant; promoting blood circulation and relieving pain. The main rheumatic pain
[ usage]: orally taken decoction, 3-6g; or leach liquor.
The clinical application of [ ]
1: Ciwujia extract of Acanthopanax senticosus ( meal ) 1 000G, 75% ethanol amount. Thorn Five Bold powder plus 7 times the volume of 75% ethanol, 12 hours of heating reflux extraction, filtration, recovering alcohol, concentrated into extract 50g, namely. This product is a dark brown thick paste; with Acanthopanax senticosus special aroma, slightly bitter taste. This product with 40 times amount of ethanol solution, the filtrate is added with 3% sodium carbonate solution 1ml and new manufacturing diazo p-nitroaniline TS 2 drops, is marked in red; the other the filtrate is added with 5% sodium nitrite solution and 10% aluminum nitrate solution was placed, with sodium hydroxide solution that was red brown. In 105 DEG C dried to constant weight, weight loss shall not exceed 20%; in accordance with the" people's Republic of China Pharmacopoeia 1990 version of" provisions of the ferric salt inspection method inspection, with the standard iron solution made of 1.5ml control solution colorimetric, shall not be deeper ( 0.003%); with 20 times amount of methanol as solvent, extract of not less than 60%. Efficacy of treating with Acanthopanax senticosus. Oral, 0.3-0.459 each time, 3 times a day. (" the people's Republic of China Pharmacopoeia 1990 2" ): Ciwujia Acanthopanax senticosus extract honey paste 175g, 200g, 3G 90ml, sodium benzoate, ethyl alcohol. Acanthopanax senticosus, to break water, decocting 2 times, filtration, filtering to obtain filtrate, concentrated to a relative density of 1.10 extract ( 80 degrees measured), put cold. Adding 3 times amount of ethanol, static, supernatant recycling ethanol and concentrated to a relative density of 1.26 paste (80 degrees C measurement). Love cream with ethanol 2, static. The supernatant recycling ethanol, add honey, alcohol, sodium benzoate, add water to the 1 000ml, stir, static, filtration, according to each branch of 10ml packaging. This product is a reddish brown transparent liquid, taste Gan - xin. This product by adding 5% sodium nitrite solution and aluminum nitrate solution and 10% 1mol / L sodium hydroxide reagent, should be marked in red, pH should be 4.0-5.0, relative density should be above 1.05. Function and benefits of God, increase appetite, hearing and eyesight, kidney and spleen. For the lack of energy, neurasthenia and disease, puerperal disorders. Oral, 10ml each time, 2 times a day, morning and evening fasting temperature boiling water send eye. (" drug standards of Heilongjiang province" in 1986 3 ) Acanthopanax granules: Acanthopanax water extract 700g, dextrin sugar 12g, 12 000g. Acanthopanax senticosus extract and 60% ethanol water amount, mix; with powdered sugar and dextrin, mixing, granulating, drying, granulation, namely. This product is light yellow granules, the solution with sodium carbonate and diazo reaction of P nitro aniline solution was reddish brown, with ferric chloride and potassium ferricyanide mixed significant green. Functions of replenishing qi to invigorate the spleen, tonifying kidney and tranquilization. For Yang deficiency of spleen and kidney, Yaoxisuanruan, weakness and fatigue, insomnia, loss of appetite. Oral, 4G each time, 2 times a day. (" drug standards of Liaoning province" in 1987 4 ) Acanthopanax tablets: Acanthopanax senticosus extract 150g accessories amount. Taking Acanthopanax coarse powder 3 000G, adding 7 times of 75% ethanol for 12 hours, filtering; recovering alcohol, concentrated into the dense extract 150g; Acanthopanax senticosus extract with thick, plus auxiliary amount, mixing, the pellet, pressing to 1000 tablets, coated with sugar. This product is removed after the brown sugar, taste bitter, astringent. This product to remove sugar, fine grinding, plus ethanol extraction liquid filtration, the filtrate is added with 3% sodium carbonate solution and the new system of P nitro aniline diazo solution is marked in red. This product with methanol as solvent determination extract, each containing extract of not less than 80mg. Functions of replenishing qi to invigorate the spleen, tonifying kidney and tranquilization. For Yang deficiency of spleen and kidney deficiency, body weakness, loss of appetite, backache, leg pain, insomnia and dreaminess. Oral, 2-3 each time, 2 times a day. (" the people's Republic of China Pharmacopoeia 1990 5" ) of compound acanthopanax senticosus syrups: Acanthopanax senticosus extract 20g, Schisandra extract flow 10g 300ml sucrose, ethanol, 300g, amount of water. Ethanol 150ml and amount of water dissolved Ciwujia extract, adding Schisandra extract flow, mix, static clarification, taking supernatant, standby. Sucrose dissolved by adding water, boil for 30 minutes, add the liquid filtration; and the residual ethanol, stir, add water to the 1 000ml, stir, filtration, packaging, that is. This product is brown viscous liquid; sweet, acid. The methanol extract and 10% - naphthol reagent, adding concentrated sulfuric acid, was purple ring; and 3% sodium carbonate solution after the freshly prepared diazonium reagent should be red. Function of Fuzheng Guben, puzzle and. For neurasthenia, malaise, spleen and kidney weakness. Oral, 20ml each time, 2 times a day. (" drug standards of Jilin province" in 1986 6 ) of Acanthopanax senticosus royal jelly tablet: Acanthopanax senticosus extract 100g, royal jelly powder 56.7g, accessories adequate. With Radix Acanthopanacis Senticosi and accessories mixing, granulation, drying, joined the royal jelly powder, mixing, pressing it into 1000 pieces, pieces of heart weight 0.22g, coated with sugar. Despite the sugar-coating was brown, slightly bitter taste. Removal of sugar, water extraction filtration to obtain filtrate, plus 0.2% indinavir three ketone test solution, purple; this product to remove sugar, fine grinding, plus ethanol extraction filtration, the filtrate is added with 3% sodium carbonate solution and the new system of P nitro aniline diazo solution 1-2, marked in red. Function of Fuzheng Guben, supplementing qi and nourishing stomach, spleen. For neurasthenia, palpitations, shortness of breath, a weak body, Yaoxisuanruan, loss of appetite; can also be used for cardiovascular insufficiency, hepatitis, ulcer disease, adjuvant therapy. Oral, 3-4 each time, 3 times a day. (" Heilongjiang drug standard" 1986) 7 senticosus Shouwu tablets: Acanthopanax senticosus extract of Radix Polygoni Multiflori 75g, 360g accessories amount, get prepared radix polygoni Multiflori 140g crushed into fine powder, sieving; another Prepared Radix Polygoni Multiflori 220g boiling water for 2 times, filtration, with the filtrate, concentration, drying, powder and fine powder. The 2 kinds of Radix Polygoni Multiflori fine powder and the auxiliary materials and preheating Ciwujia extract mixing, granulation, drying, pressing to 1000 tablets, coated with sugar, that is. Each substrate weight 0.26g. After removing icing yellow brown, taste bitter, astringent.
7.1. This product to remove sugar fine grinding, adding methanol shaking, filtration. Take the filtrate is added with 10% naphthol ethyl alcohol solution of 1-2 drop, shake, along the pipe wall and sulfuric acid 1ml, shows purplish red ring; and the filtrate is added with 3% sodium carbonate solution and preparation of diazo p-nitroaniline solution 1-2, namely, marked in red.
7.2. Take the fine powder, another system Shouwu powder 0.5g, Radix Acanthopanacis Senticosi, respectively adding methanol reflux, filtration, the filtrate to the same paper chromatography, with acetic acid and hydrochloric acid - water ( 30 : 3: 10) uplink spread out to dry,, post observed under an ultraviolet lamp: Shouwu liquid and for the sample solution in the corresponding position of the spots show bright purple fluorescence. Acanthopanax senticosus extract solution and sample solution in the corresponding position of the spots show bright blue fluorescence. Function of Fuzheng Guben, tonifying liver qi, invigorating kidney and replenishing essence, nourishing and soothing. Used for liver and kidney yang deficiency, Yaoxisuanruan, numbness of limbs, early white hair, blood deficiency frail, insomnia, loss of appetite and so on. Orally, 4 tablets each time, 3 times a day. (" drug standards of Heilongjiang province" in 1986 8 ) Acanthopanax senticosus Guiqi fine: Acanthopanax 200g 200g 100g, astragalus, angelica, honey, 500g 2G, sorbic acid, citric acid and sodium 6g. Taking Acanthopanax boiling water for 4 times, filtration, filtering to obtain filtrate, concentrated to the syrupy; adding 3 times amount of 95% alcohol, filtering, concentrating, placement, and gelatin solution to precipitate, adding 5 times amount of 95% ethanol, placing the filtration, concentrating into thick paste spare. Take the Astragalus, angelica decocting 3 times, filtration, filtering to obtain filtrate, concentrated to the syrupy; at 3 times the volume of 95% ethanol 3 times into thick paste, concentrated backup; the honey is heated to melt, the Acanthopanax senticosus, astragalus, angelica extract dissolved by adding water filtration, the filtrate in the honey, stir well, adding sorbic acid alcohol solution and sodium citrate solution, distilled water to 1 000ml, standing for 2 days, filtration packaging. This product is orange viscous transparent liquid, sweet. PH 4.5-5.5 1.14-1.16, relative density. Function of Fuzheng Guben, Buqi solid table, nourishing the blood. For valetudinarianism, insomnia, spontaneous perspiration, Yaoxisuanruan, shortness of breath, palpitation. Oral, daily 1-2 times, each time 10ml. (" drug standards of Jilin province" in 1986 9 ) of Acanthopanax senticosus tonic: Acanthopanax senticosus Schisandra 80g 400g, medlar, 125g 80g 200g 700g honey Astragalus, caramel, amount of essence. Take the medicine four taste, they shall be crushed. By 4 times the volume of 70% ethanol 2, filtration; with the filtrate, recovering alcohol, concentrated into paste, the paste with honey and caramel flavor, blending, made 1 000G, packaging. This product is yellowish - brown thick semi fluid; sour. The cream and honey and caramel flavor, blending, made 100%, packaging, the product is yellow-brown thickened semi fluid; sour, sweet. With the amount of total flavonoids by rutin calculation should not be less than 45% ( mg / g ), function of kidney qi, nourishing heart for heart and kidney weakness, fatigue, shortness of breath, insomnia dreaminess, dizziness, forgetfulness, Yaoxisuanruan, impotence, seminal emission. Hot water, 1 teaspoon ( about 20g) each time, 3 times a day. (" Heilongjiang drug standard" 1986) 10 compound acanthopanax tablets: Acanthopanax senticosus extract Polygonatum 200g 50g, 100g 100g, astragalus, Angelica sinensis, vitamin B1 5G. More than five taste, astragalus, angelica and Polygonatum 1 / 2 weight crushed into coarse powder, according to the percolation method, using 60% ethanol as solvent, lawfully made fluid extract; the rest of Polygonatum crushed into fine powder, sieving; the radix acanthopanacis Senticosi, the liquid extract, powder, vitamin 1 and the amount of materials mixing, granulation, drying, pressing it into 1000 pieces, pieces of heart weight 0.37g, coated with sugar. This product is removed after icing, brown, slightly bitter taste. Function of Invigorating Qi and nourishing blood, tranquilizing puzzle, fill the stomach and spleen, centralizer. Two for the blood loss caused by general weakness, heart palpitations, insomnia, loss of appetite and so on. Oral, each 2-3 2-3, daily times. (" drug standards of Heilongjiang province" in 1986 11 slender acanthopanax ginseng and gecko ): Acanthopanax 130g gecko ( fish, cephalopods ) 2.4G, 50g 50g Cistanche, ginseng, ginseng juice ( processing red ginseng or ginseng distilled liquor ) 350ml. More than five taste, Ciwujia Ciwujia extract of gecko made; crushed into coarse powder, adding dilute ethanol 30ml, dipping 7 days later, filtration, recovering alcohol, concentrating to 60ml, adding 3 times amount of ethanol, stirring, standing for 24 hours, filtering, recovering alcohol, concentrated into 6ml Cistanche crushed into coarse; powder, heating reflux extraction for 2 times, each time for 2 hours, merging extracted liquid, filtering, concentrating to 5ml, plus ethanol, standing for 24 hours, filtering, concentrating the filtrate to taste, add appropriate distilled water dissolution, filtration; ginseng they shall be broken off, adding 3 times amount of dilute ethanol refluxing extraction for 5 times, with extraction liquid, concentrating, adding 3 times amount of ethanol, stirring, standing for 24 hours, taking supernatant other place, precipitation with 3 times the volume of 65% ethanol elution, and supernatant with eluents, recovering alcohol, concentration to right amount, made from sucrose syrup, add ginseng concentration liquid, mixing, blending, adding water into 500ml. The radix acanthopanacis Senticosi, tokay, desertliving Cistanche add distilled water dilution after adding ginseng syrup, ginseng lotion 350ml and sorbic acid ( 1.14g gliadin ), mixing, adding water to 1 000ml, low temperature static, filtration, the filtrate is added with an amount of essence, mixing, packaging, each branch of 10ml. This product is brown yellow transparent liquid; gas fragrant, sweet, bitter. PH for 4.0-5.0. Functional tonifying the lung qi, tonifying blood. For the energy loss, Feixu cough, after the disease. Oral, 10ml each time, 2 times a day. (Department of health" drug standard of Chinese traditional patent medicine" ( second volumes) 1990) 12: Ciwujia injection and acanthopanax senticosus (whole plant ) 1 000G, injection water amount. The acanthopanax whole-plant pulverization, Decoction on mercaptan method treatment, the filtrate is added with active carbon amount, filtration; the injection water is added to 1 000ml, potting, sterilization, namely. Each branch of 20ml, each 1ml containing total flavonoids by rutin calculation, shall not be less than 5mg, brown transparent liquid, pH should be 6.0-7.0. Function expansion of blood vessels, increasing coronary blood flow, reducing myocardial oxygen consumption, improve blood circulation, and have a calming effect, can improve sleep, increase appetite. For transient ischemic attacks, cerebral arteriosclerosis, cerebral thrombosis, cerebral embolism; also used for coronary heart disease, angina pectoris with neurasthenia and menopausal syndrome. Intravenous infusion, daily 1-2, 20-40ml each time, add 5% or 10% glucose injection in 500ml. (" Heilongjiang drug standard" 1986";" Pharmaceutical Bulletin 1986, 21 ( 10) : 601. )
Excerpts from" Chinese Materia Medica" [ ]
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