Big Ma Weilian

[ source ] from the" Zhejiang temmokus yam planting Zhi"
Pinyin name ] [ Dà Yè Mǎ Y Liá nì Ji
[ English ] Root and Rhizome of Faber name Meadowrue
[ source ]
Medicine medium source: as in Ranunculaceae Thalictrum faberi, pointed leaves Thalictrum and Thalictrum root and rhizome.
Latin botanical mineral name: 1.Thalictrum faberi Ulbr.[T.Macrophyllum animal Migo]2.Thalictrum acutifolium ( Hand.-Mazz. ) Boivi[T.clavatum DC.var.acutifolium Hand.-Mazz.]3.Thalictrum fortunei S.Moore
Harvest and storage: from spring to autumn harvest, cut off the stems leaves, fresh or dried.
[ ] the original morphology
1Thalictrum faberi, perennial is herbaceous, tall 35-110cm. Glabrous. Rhizome short, a majority of fibrous roots. Stems erect, branched distally. Ye Wusheng; petiolar long 4.5-6cm, base sheathing; stipules narrowly, entire; basal leaves in blossom withered, lower stem leaves two to three to three leaves; leaves up to 30cm; leaflets, firmly papery, broadly ovate or nearly rhombic, long 5-10cm, wide 3.5-9cm, apex acute or obtuse, base rounded, shallowly cordate or truncate,3lobed, margin of each side of5-10ranging from large coarse teeth, above vein nearly flat, the following veins bulge, reticulate veins conspicuous; petiolule length 1.5-4cm. Paniculate inflorescence, long 20-40cm; flowers bisexual, pedicels slender,3-7mm long; sepals 4, petaloid, broadly elliptic, long 3-3.5mm, white, caducous; no petals; stamens numerous, filaments than anthers narrow or wide, long 5-7mm, lower filamentous, anthers oblong, long 1-2mm; carpels 3-6, style and ovary equal, slightly circinate, stigma on the ventral surface of. Achenes narrowly ovate, long 5-6mm, about 10of the longitudinal help, persistent style ca.1mm, circinate. Florescence 7-8 month, month of fruit period 8-9.
2pointed leaves Thalictrum, perennial is herbaceous, tall 25-65cm. Leaves abaxially glabrous or sometimes sparsely pubescent. Roots fleshy, carrot-shaped, about 5cm long, rough up to 4mm. Stem erect, branched above middle. Ye Husheng; petiolar long 10-20cm; basal leaves 2-3; two to three leaves; leaf blade long7-18cm; leaflets herbaceous, ovate, long 2.3-5cm, wide 1-3cm, apex acute or obtuse, base rounded or cordate, the wedge, is not split or not apparent 3lobed, margin sparsely teeth; cauline leaves a small a short handle. Compound monochasium a corymbose, glabrous; flowers bisexual, pedicels3-8mm long; sepals 4, petaloid, ovate, ca.2mm, white or pinkish, caducous; petals absent; stamens many,5mm long filaments, upper than the anthers broadly, lower filamentous, anthers oblong, long 0.8-1.3mm; carpels 6-12, a shank, styles short, stigma on the ventral surface of. Achenes narrowly oblong, flat, slightly asymmetrical, sometimes bending, long 3-4.5mm, wide 0.6-1.2mm, has 8longitudinal, fruit handle is long1-2.5mm. Florescence 4-7 month, month of fruit period 5-8.
3Thalictrum, perennial is herbaceous, tall 20-70cm. Glabrous. Lower part of stems or branches. Ye Husheng; petiole ca.6cm, base sheathing; stipules membranous, semiorbicular, margin entire; leaves two to three to three leaves; leaflets herbaceous, obovate or suborbicular,1-2.5cm long,0.8-2.3cm wide, apex rounded, base rounded or shallowly cordate, obscurely 3 - lobed or5-7shallowly crenate, veins beneath uplift, reticulate veins conspicuous. Monochasium, flowers bisexual, pedicels slender,0.6-1.6cm long; sepals 4, petaloid, obovate,3-4.5mm long, white or pale purple, caducous; petals absent; stamens numerous, slightly wider than anther filaments, narrow lower portion, anthers elliptic, long 0.5-1.2mm, apex obtuse; carpels 3-6, oblong, long 2-2.5mm style short, curved, apex, stigma on the ventral surface of. Achenes cylindrical spindle, long 4-5mm,6-8longitudinal help, persistent style long 1-1.2mm, apex circinate. Florescence 4-5 month, month of fruit period 5-7.
[ ] habitat distribution
Ecological environment:1 born in altitude 600-1300m mountain forest.
2born in the mountain, forest margins and wet places in valleys or.
3 born in hilly areas or mountainous forest wet places.
Resource distribution:1located in Jiangsu, Anhui, Zhejiang, Jiangxi, Fujian, Henan, Hunan.
2located in Anhui, Zhejiang, Jiangxi, Fujian, Hunan, Guangxi, Guangdong, Sichuan, Guizhou.
3located in Jiangsu, Anhui, Zhejiang, Jiangxi.
[ character ]
1character identification lobar Thalictrum grass rhizome short, lower dense dozens of fine root. Fine root length of about 10cm, about 1mm in diameter; Tan surface, the loose skin; hard and brittle, easily broken; bitter taste.
2microscopic identification of Thalictrum faberi root transection: epidermal cells of 1 columns, some visible hair. Cortex has stone cells scattered in the endothelial layer obviously. Phloem is wide. Central to the epigenetic nature, periphery has large fiber 4beam and xylem bundle spacing.
[ ] the chemical composition
After1 big don root contains lobar Tang Song alkaline (thalifaberine), Thalictrum faberi bin alkali (thalifabine ), yellow ( hangshanine ), brake spirit to hydrogen yellow brake Ling (dehydrohuangshanine), Thalictrum faberi fixed alkali ( faberidine ), Thalictrum faberi Ba Ting alkali (thalifabatine ), hydrogen (dehydrothalifaberine ), big Tang Song from C. Thalictrum star alkali (thalifasine ), Thalictrum faberi pull goods alkali ( thalifarapine ), Thalictrum faberi Heinonen alkali ( faberonine ), Thalictrum faberi laning alkali (thalifaboranine ), big Ye Tangsong orchid fixed alkali (thalifalandine ), Thalictrum faberi lamin alkali (thalifaboramine ), Thalictrum rochebrunianum alkaline ether ( O-methylthalibrine ), Thalictrum berberine ether ( O-methylthalicberine ) wrinkle, Thalictrum fixed alkali ( thalrugosidine ), Thalictrum Shu Ping alkali ( thaligosine ), deep yellow pansy alkali ( pallidine ), N- demethylation thick fruit thalidasine ( N-demethylthalidasine ), thick fruit thalidasine ( thalidasine ), small Thalictrum teacher alkali (thaliracebine), Thalictrum Nanjing alkali (thalifinine), berberine ( berberine ), jatrorrhizine ( jatrorrihizine ), magnoflorine ( magnoflorine ) and fumaric acid ( fumaric acid ), palmitic acid ( palmitic acid ),β- sitosterol (β -sitosterol ),5- -7- three hydroxy flavone (3,4',5-trihydroxy-7-methoxyflavone ).
2pointed leaves Thalictrum rhizome containing oxidation of berberine (oxyberberine ), pointed leaves Thalictrum fixed alkali ( acutifolidine ), Cocculus trilobus Ning alkali (trilobinine ), palmitic acid methyl ester ( methyl palmitate ), linoleic acid ( methyllinoeate ),β- sitosterol (β -sitosterol ), thirty-five ( pentatriacontane ), is an alkyl ( twenty-nine nonacosane ).
3Thalictrum rhizome and East Thalictrum alkaline (thalifortine ), arrow Mo Ling base (aromoline ), N- -2- ( N-phenyl-2-naphthylamine ) phenyl naphthylamine.
[ ] the pharmacological effect
1anticancer effects of Thalictrum fargesii in raw fruit Pinus uncinata alkaline has significant anticancer activity, intraperitoneal injection of 70mg / kg,1 times a day,10d, on Ehrlich ascites tumor inhibition rate was 50%, S180 was 25% on mice sarcoma. Daily subcutaneous injection of 42mg / kg,7d, W256on rat Wacker sarcoma38.8%, daily intraperitoneal injection of 100mg / kg,10d, Lewis lung cancer in mice was 50%-58%,200mg / kg on rat W256 has significant inhibitory effect. Thick fruit thalidasine made of POLYPHASE LIPOSOME of anticancer activity increased after.
Antibacterial effect of2thick fruit thalidasine in0.1mg / ml on Staphylococcus, Streptococcus, Escherichia coli, Klebsiella pneumoniae, Pseudomonas, Bacillus septicaemiae, dysentery bacillus, bacillus, Salmonella typhimurium, Candida albicans and Salmonella inhibit. In addition, Thalictrum faberi contained in Thalictrum teacher alkali and Thalictrum Nanjing alkali also had significant inhibitory effect, the smegma Bacillus minimum inhibitory concentration ( MIC ) were 0.1mg / ml and 0.05mg / ml, and thick fruit thalidasine is 0.025mg / ml.
3Effects on the cardiovascular system thick fruit thalidasine, Thalictrum teacher alkali and Thalictrum Nanjing alkali are hypotensive effect, thick fruit shop don alkaline4mg / kg intravenously to rabbits, can make blood pressure drops2.39kPa, duration 3min, Thalictrum teacher alkali infusion of 0.1mg / kg, decreased blood pressure2.66-2.93kPa, role of persistent30s; Thalictrum Nanjing alkali infusion of 0.1-1mg / kg, can make blood pressure drops1.33-3.06kPa, maintain 30s.
4the in vivo process of hydrochloric acid thick fruit thalidasine and POLYPHASE LIPOSOME to mouse single tail vein injection of24mg / kg, concentration time curve are consistent with the opening of two compartment model, double exponential equation were C = 21.446e\-0.536 +4.356e\-0.0623t and C=23.73e\-0.1972t +1 203e\-0.0294t. Theα,βphase half-life were1.293,11.12min and 3.52,23.58min, two forms of pharmacokinetic processes have significant differences, liposomes of the thick fruit thalidasine in blood to maintain higher concentrations and longer duration.
Toxicity of 5thick fruit thalidasine mice intraperitoneal injection of LD50520mg / kg,120mg / kg intravenous injection.
[ ] taste bitter cold;
[ ] is owned by E.; liver by
[ indications ] clearing heat and purging fire; detoxification. The main indications of dysentery; diarrhea; swollen red eyes; damp-heat jaundice
[ usage]: orally taken decoction,3-10g. External application: suitable, grind end, attune spread.
[ note ] Shen clothing of spleen deficiency.
Clinical application of treating diarrhea abdominal pain [ ], eyes red and swollen pain. Gen one or two, water simmer in water, red sugar, morning and evening meals every day.
Excerpts from" Chinese Materia Medica" [ ]

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