2012年5月24日星期四

Sargentodoxa cuneata



[ source ] from simple" herbal".
Pinyin name ] [ Dà Xuè Té n
English name [ ] Stem of Sargentgloryvine
[ alias ] were, siphon, title, Homalomena, Draconis, blood, blood, blood fly through, Huang To, red, blood components were, streaky, blood sausage, flowers were Akasa To, Yama Kureto, were, and vine.
[ source ]
Medicine medium source: cuneata Lardizabalaceae plant stems.
Latin animal mineral name: Sargentodoxa cuneata ( Oliv. ) Rehd.et Wils.
Harvest and storage:8-9 month recovery, removal of leaves, abluent, cut the length of about 30-60cm, or sliced, dried.
[ ] the original morphology of Sargentodoxa cuneata deciduous woody vine, up to 10m. Stem cylindrical shape distortion, brown, cut off when mixed with a red sap. Three leaves alternate; has a long handle; the middle leaflet obovate, long 7-12cm, wide 3-7cm, side unripe flocculus is larger, obliquely ovate, apex acuminate, base asymmetrical. Flowers unisexual, female dioecious, racemes from the last leaf armpit base, up to 12cm, pendulous; sepals 6; petals 6, yellow; male flowers with stamens6, opposite petals; female flowers with staminodes6, carpels numerous, free, spirally arranged, ovules 1grain. Berry fleshy fruit stalk, most inserted in a spherical torus. Seeds ovoid, black, shiny. Florescence 3-5 month, fruit is ripe period8-10 month.
[ ] habitat distribution
Ecological environment : in the mountains, sparse forest mountain ditch banks fertile soil in the bushes.
Resource distribution: distribution in South and Shaanxi, Anhui, Jiangsu, Zhejiang, Jiangxi, Fujian, Sichuan, Guizhou, Yunnan and other places.
[ ]1of climate and soil cultivation in low hill region on both sides of the creek and the edge of the forest, deep fertile soil, good drainage of sloping land is appropriate. 2generally planted mainly to layering propagation. Sichuan region deciduous in winter, the plant long stem branching, respectively, around and about 30cm in diameter circle, every branch 1ring, in line next to the open hole, the ring oblique hole, and then cover soil compaction, the half circle ground, half of the circle is exposed on the ground, in the soil in the half to take root, the half above the ground to grow new branches. To winter will press the branch to dig, in accordance with the root growth, its cut, make plant. Then the chosen land, according to1-1.4meters spacing opening point, point to deep, to put the new strains of vines planted into2/3 long good. After planting soil matter, and proper watering. 3field management on the edge of the forest tracts of cultivated in first,2 years, proper weeding, fertilizing.
[ character ]
Character identification of stem cylindrical, slightly curved, through bending, length 30-60cm, diameter 1-3cm. Surface gray-brown, rough, scaly peeling skin often significant dark brown, some visible enlarged nodes and slightly concave branch marks or scars. Soft skin, red brown section, several inwards embedded in the wood, wood white, has a plurality of fine holes of different tube, bulk groove arranged radially, ray. Gas micro, taste slightly astringent.
Microscopic identification of the transverse section of the stem: cork for columns of the surface cells, cells containing reddish brown. Stone cells in cortex constant flocks, sometimes with calcium oxalate crystal. Vascular monocyclic type. Phloem secretion cells often tangentially arranged with intervals, screen group; there are a few stone cells scattered in the. Fascicular cambium clearly. Xylem of multiple distributed in single, round, a diameter of about 400μ m, the surrounding wood fiber. Ray wide, lateral stone cell is more, some containing a number of calcium oxalate crystal. The pith of visible stone cell group. Parenchyma cells contain brown or red brown.
[] used chemical composition containing emodin (emodin), emodin monomethyl ether (physcion), β - sitosterol (β -sitosterol), daucosterol (daucsterol), stearic acid (stearic acid), Moto (salidroside), dextral syringaresinol two glucoside (syringaresinol bisglucoside), with two hydrogen guaiac acid (dihydroguaiaretic acid), chrysophanol (chrysophanol), homovanillic acid (vanillicacid), protocatechuic acid (protocatechuic acid) and p-coumaric acid - hydroxy phenyl ethyl ester (p-hydroxyhenylethylcoumarate) and emodi polysaccharide.
[ ] the pharmacological effect
1Effects on the cardiovascular system1.1on isolated toad heart function by Yagi 's isolated heart device, to20ml Ringer solution perfusion,0.1g will join in the perfusate of Sargentodoxa cuneata (0.5%), found on the isolated heart showed a mild inhibition performance, systolic force is abate, slowing of the heart rate ( P < 0.05), decreased cardiac output ( P<0.01).
1.2 on isolated rabbit aortic strips will be the role of isolated rabbit aortic strips, in isolated device water tank (37±0.5) placed LH,0.2ml extract (1g : /ml ) by adding 20ml grams 's solution (1%), blood vessels begin to appear obvious contraction effect, the effect may be phenol Title phentolamine antagonizes the contraction, may be associated with a- receptor. Then gradually lasting relaxation.
1.3 on isolated porcine coronary artery function experiment method ibid.,0.2ml extract by adding 20ml grams 's solution, to norepinephrine and potassium chloride as positive and negative reaction control, out of hours and the role of rabbit aortic strips similarity. But in the KCl-induced contraction state, adherence to medications, then contraction does not appear, but immediately relax blood vessels, tips for treatment of coronary artery spasm favorable.
1.4 pairs of animal experimental myocardial infarction in rabbits1.4.1were water soluble extract on experimental myocardial infarction in rabbits and the effects of water soluble extract of traditional Chinese medicine of Sargentodoxa cuneata ( with 95% ethanol immersion, decompression concentration, ethyl ether extraction for removal of ether soluble substances, adding water to the syrup form precipitate precipitation does not occur again, filtering out the precipitation, Gelfoam to solution precipitation will no longer generate, water solution is concentrated by reducing pressure into a syrupy, extracted with methanol, methanol insoluble, water solvent, containing sugar and glycosides ). From24 healthy rabbits, were randomly divided into 3 groups, control group ( equal volume of physiological saline of Sargentodoxa cuneata ), water soluble extract group (100mg/kg; a crude drug, propranolol group100g ) (0.05mg/kg ). With sodium pentobarbital anesthesia (300mg/kg ) IV, were chest multiple lead electrocardiograms mapping. Thoracotomy, in the left anterior descending branch of the root with 4silk ligation. Closed chest, chest ECG tracings immediately after the IV drugs, after every 6 hours bolus injection of1, a total of 4 times. In4 hours after ligation and24 hours respectively for electrocardiographic mapping. 24 hours after the test out at heart, myocardial infarction range percentage calculation, results all rabbits in the ligation of the left anterior descending artery after 4hours, experiment group and propranolol group electrocardiographic ST segment elevation of total millivolt values ( sigma-delta ST ) are similar, the two groups were significantly lower than those in control group ( P < 0.05. In24 hours after ligation differences are more significant ( P < 0.01. In24 hours after ligation of Sargentodoxa cuneata group, MI narrowed down to19.17%, with19.88% similar to propranolol group, compared with the control group, the differences were highly significant at P < 0.001. At the same time also had a myocardial infarction in rabbits of myocardial lactate content determination:42 rabbits were divided into 4 groups : normal group, ligation of the left anterior descending artery, also do not give any drugs, other3 groups of ligation of the left anterior descending artery, and in the electrocardiogram, myocardial infarction group ivlmg/kg normal saline group, O To ivl00mg/kg weight,0.05mg/kg IV Inderal propranolol group weight. Simultaneous determination of 4 components in every experiment of rabbit myocardial tissue within the content of lactic acid. Results prior to administration, myocardial infarction control group, experiment group and propranolol group averageΣ△ ST difference was not significant ( P > 0.05). Reveal the ligation of the left anterior descending artery induced myocardial ischemia extent between the 3 groups may substantially similar. Myocardial infarction animal to saline or drug after L hours, myocardial infarction group at l hours after myocardial infarction, myocardial tissue in lactic acid content increased significantly, and the experiment group and propranolol groups were not increased ( with normal myocardial lactate content similarity), difference is very significant ( P < 0.001), suggesting the used water soluble extract can improve myocardial lactate metabolism disorder.
1.4.2cuneata water soluble extract on experimental myocardial infarction in dogs experimentally the effects of using established in 19 dogs, were randomly divided into 3 groups: myocardial infarction control group, in the ligation of the left anterior descending artery without any drug treatment; experiment group, in the ligation of the left anterior descending branch at the same time, ivl00mg/kg, after repeated every 6 hours in 1, a total of 4 times; the propranolol group, in the ligation of the left anterior descending branch at the same time,0.5mg/kg IV propranolol, after every 6 hours injected 1 times,4 times in total. The results show that, experiment group in the ligation of the left anterior descending artery after 5minutes the epicardial electrocardiogram ST segment and the control group obviously raised, and there was no significant difference in P < 0.05. But the elevation of the ST segment and fast recovery, in30 minutes after occlusion, compared with the control group, there is significant difference, P < 0.05. And propranolol groups, O To's role is slow and weak. Experiment group for30 minutes after occlusion of the femoral artery blood pressure heart rate and little impact, but left ventricular peak pressure drop and left ventricular end diastolic pressure increased, both changes in amplitude compared with the control group, the difference was significant at P < 0.05. Blood lactic acid content and myocardial infarction in rabbits results in myocardial tissue lactate changes consistent. Myocardial infarction range of Sargentodoxa cuneata group, narrowing the scope of myocardial infarction, compared with the control group, the difference was significant at P < 0.001. Propranolol group effect is more obvious, but with the experiment group comparisons revealed no significant difference in P < 0.05.
Water soluble extract of100mg/kg1.4.3treated by intravenous injection, can make the experimental myocardial infarction in rabbits have elevation of the ST segment decreased significantly, improve the ligation of the left anterior descending coronary artery induced myocardial lactate metabolism disorders, and reduce the myocardial infarction area.
1.5of Sargentodoxa cuneata water soluble extract on isoproterenol ( ISO ) - induced rat myocardial ischemia rats weighing 150-200g, were randomly divided into treatment group ( Lriodendrin, wool willow glycosides, polysaccharides are5mg/kg2mg/kg, propranolol ) and the control group with normal saline ( NS ), each 0.5mL, a total of in 5 groups, with 15 rabbits in each group. The administration of Ip30-40 after minute, anesthesia and limbs and ECG machine coupling, determination of limb standard leadⅡEKG, ISO4mg/kg (IP) were observed in 1,5,10,30,60 minutes when EKG changes. 24hours later, according to the day before delivery, recording the sequence repeat. 48 hours after anaesthesia, measuring EKG after thoracotomy coring, producer, carried on the pathology examination. The results of Sargentodoxa cuneata polysaccharide on EKG changes, dlP < 0.05, d2P < 0.01. To have potential therapeutic significance, pathological examination of myocardial necrosis in the protective effect of the strongest ( P < O.01). Liriodendrin on EKG is weak wait, to D2 only difference ( P < 0.05), pathological examination also has protective effect ( P < 0.05). Mao Liu glycosides group and saline control group had no significant difference between. Plant polysaccharide has the enhancement or suppression of immune function, the past has not been reported against myocardial ischemia. Its mechanism of action is worthy of further study.
1.6 on the blood pressure of anesthetized cats effect on the health of4 cats, after anesthesia tracheal intubation by conventional, casing, separation and measurement of carotid blood pressure, shares of iv0.1g/kg cuneata water extract (1g crude drug is1ml ), there was a transient hypotensive effect, this effect can be blocked by atropine; removal of two measured vagal, hypotensive effect of no effect, prompting its hypotensive effect can be associated with peripheral cholinergic system.
2in mouse plasma cyclic nucleotide effects in Toriken Yasuo guinea pigs, weight 18-24g, divided into 3 groups, each group5, group first day IP cuneata water extract of3g/kg (1/4LD50), second groups of every IP Danshensu200mg/kg, third groups of every IP saline as a control, for 7 consecutive days, in the day after delivery after L hours, orbital blood, determination of plasma cAMP and cGMP. The results of experiment group and control group were significantly increased plasma cAMP content, cCMP content was less. Another mouse, n = 5, ip3g/kg 1 times every 15,30,90, and 120minutes, respectively from the orbital blood, saline control group. Effects of different time of plasma cAMP and cGMP change. The results showed that at 50 min after administration, cAMP and cGMP were increased, cAMP increased more significantly. CAMP/cGMP decreased, but in 60minutes, cAMP and cCMP were gradually decreased, cAMP/cGMP rise. Water soluble extract of Caulis Sargentodoxae100mg/kg, so that the rabbit plasma cAMP increased significantly.
3Effect on platelet aggregation of Sargentgloryvine Stem water soluble extract in vitro test on ADP induced rabbit platelet aggregation have obvious inhibition and facilitation of depolymerization, ID5014.6mg/ml. Water soluble extract of Caulis Sargentodoxae40,100mg/kg on rat ADP induced platelet aggregation inhibition. This product is dichloromethane extraction sites, including two hydrogen guaiac acid, can inhibit PAF ( platelet activating factor receptor ) and combination.
4 pairs of mice under normal pressure hypoxia influence Toriken Yasuo mouse, weight 17-22g, divided into 3 groups,10 rats in each group, cuneata water extract ( /kg2G quite crude drug), mouse IP LD50was l1.83 ±2.12g/kg ), controlled by the same volume of normal saline, the timing was observed, with cessation of breathing for death indicators, the results show that in the different time have obvious effects.
5bacteriostasis with plating method test,25% Decoction of Staphylococcus aureus, Streptococcus have extremely sensitive antimicrobial effect, Escherichia coli, Pseudomonas aeruginosa, Streptococcus viridans, catarrhal coccus, Staphylococcus albus have high sensitive bacteriostasis.
6 on animal gastrointestinal smooth muscle function to mice or guinea pig isolated intestinal segments, in the 20ml continuously air Rockwell liquid,1% and5% of Sargentodoxa cuneata on mouse intestinal segment when the obvious inhibitory effect. The guinea pig is only 0.5% and2.5% showed that after the first excitement inhibition, large dose but also weakened the role of acetylcholine. On small intestinal peristalsis of mice experiments showed that5-10g/kg cuneata water extract can significantly inhibit the peristalsis in mice speed.
7other functions of the goods and paeonol with prevention of intra-abdominal adhesions in experimental animal. Mao Liudai has the antifatigue effects; the role of phosphodiesterase Liriodendrin inhibition of cAMP.
[ processing ] water immersion, cleaning mud, run through, sliced, dried.
[ ] bitter taste; flat; non-toxic
[ ] to the liver; the large intestine meridian
[ indications ] Jiedu Xiaoyong; Huoxue Zhitong; Qufeng desiccant; insecticidal. The main acute appendicitis; diarrhea; lacteal painful; dysmenorrhea; amenorrhea; traumatic injury; rheumatoid arthritis; bug to accumulate abdominal pain
[ usage]: orally taken decoction,9-15g; or, the leach liquor wine cooking. External : moderate; pound apply affected part.
[ note ] pregnant women take it carefully.
[ the author
http://chinese-herbal-medicines-directory.blogspot.com/

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